Nonlinear Nanomechanical Mass Spectrometry at the Single-Nanoparticle Level
نویسندگان
چکیده
منابع مشابه
Towards single-molecule nanomechanical mass spectrometry
Mass spectrometry provides rapid and quantitative identification of protein species with relatively low sample consumption. The trend towards biological analysis at increasingly smaller scales, ultimately down to the volume of an individual cell, continues, and mass spectrometry with a sensitivity of a few to single molecules will be necessary. Nanoelectromechanical systems provide unparalleled...
متن کاملToward single-molecule nanomechanical mass spectrometry
Mass spectrometry provides rapid and quantitative identification of protein species with relatively low sample consumption. The trend towards biological analysis at increasingly smaller scales, ultimately down to the volume of an individual cell, continues, and mass spectrometry with a sensitivity of a few to single molecules will be necessary. Nanoelectromechanical systems provide unparalleled...
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Nanoelectromechanical systems (NEMS) resonators can detect mass with exceptional sensitivity. Previously, mass spectra from several hundred adsorption events were assembled in NEMS-based mass spectrometry using statistical analysis. Here, we report the first realization of single-molecule NEMS-based mass spectrometry in real time. As each molecule in the sample adsorbs on the resonator, its mas...
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Current approaches to mass spectrometry (MS) require ionization of the analytes of interest. For high-mass species, the resulting charge state distribution can be complex and difficult to interpret correctly. Here, using a setup comprising both conventional time-of-flight MS (TOF-MS) and nano-electromechanical systems-based MS (NEMS-MS) in situ, we show directly that NEMS-MS analysis is insensi...
متن کاملMass detection with a nonlinear nanomechanical resonator.
Nanomechanical resonators having small mass, high resonance frequency, and low damping rate are widely employed as mass detectors. We study the performance of such a detector when the resonator is driven into a region of nonlinear oscillations. We predict theoretically that in this region the system acts as a phase-sensitive mechanical amplifier. This behavior can be exploited to achieve noise ...
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ژورنال
عنوان ژورنال: Nano Letters
سال: 2019
ISSN: 1530-6984,1530-6992
DOI: 10.1021/acs.nanolett.9b00546